Clonidine is an α2 adrenoreceptor and imidazoline receptor agonist which has analgesic, sedative, and minimum alveolar anesthetic concentration-sparing effects. It has been used orally, IV, and epidurally. In spinal surgery, there is a reluctance to use local anesthetic-based epidural analgesia postoperatively because of fears of masking important signs of nerve root or spinal cord injury. This pilot study examines the analgesic efficacy of low-dose epidural clonidine after simple spinal surgery.
Continua a leggere l’articolo completo: The Analgesic Effect of Epidural Clonidine After Spinal Surgery: A Randomized Placebo-Controlled Trial